Karen Duffy, 56, looks healthy at George Clooney AFI event #Hollywood #360WiseMedia [Video]

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Heidi Parker For Dailymail.com

She had a thriving career as an MTV VJ in the Nineties.

But then Karen Duffy was diagnosed with a rare form of the disease sarcoidosis called neurosarcoidosis. Her brain and spinal cord were affected, leaving her partially paralyzed.

So it was nice to see the 56-year-old star looking healthy when she attended good friend George …

Still stunning: Karen Duffy, 56, looked healthy at the George Clooney AFI event in Los Angeles on THursday

They go way back: The beauty with Clooney as well as his ER co-star Noah Wyle in 2004

They hit the red carpet together: Clooney and Duffy at Emmy Awards in 1995

They look good together: Clooney and his wife Amal lit up the event

At the event Karen wore a fun black dress that was off the shoulder and had thin straps
She added gold pointy shoes that were slides

Besties for decades: The New York native was seen with her longtime friend Bill Murray

Glam slam ma'am: She wore her raven hair short and down with a punch of red lipstick

Good conversation: They were also seen sitting side by side at their table where they enjoyed a meal and wine

Red hot! Jane Seymour sizzled in a tight red dress on the red carpet

Her love: Not seen was her longtime beau, British film producer David Green. They have been together for over four years. Seen in 2017

A favorite: She won raves for her romantic 1980 time traveling film Somewhere In Time with Christopher Reeve

The happy couple: Amal spoke for the first time about her husband George  and their twins

Elegance: Amal's professed: 'I met George when I was 35 and starting to become quite resigned to the idea that I was going to be a spinster. Then we met and started hiding out in my London flat and very soon it felt like, no matter what happened, I would never want to be with anyone else'

Pretty! For the occasion, the human rights attorney chose a sparkly pink affair that fell all the way to the ground
 Peek-a-boo! The garment lacked shoulder straps, and featured a wide split on the left side that showcased her lithe legs

Perfect pair: Throwing their support behind their good pal, Cindy Crawford, 52, arrived in an exquisite white gown while she was joined by her husband and George's business partner in his tequila brand, Rande Gerber, 56

Did they plan it? She was joined by fellow Friends star Courteney Cox, 53, who also went with a black dress, which was asymmetrical as well

Flattering! One of his longest running co-stars was present, in his ER on-screen wife and the mother to his fictional twins, Julianna Margulies, 51, also chose black, though her garment featured tulle material to honour her former colleague and pal

Never boring! Last year's AFI honouree Diane Keaton took to the stage, where she humorously referenced George's relationship with Abraham Lincoln. She wowed in a funky black coat with a top hat and tough boots.

Head-turner: Cate Blanchett, 49, donned a very unique black dress with sheer sleeves emblazoned with ornate, tattoo-like designs
Edgy! Her dress also featured a plunging neckline

Fashionable! Another former colleague of George came in the form of Laura Dern, 51, who opted for a midnight blue number with a swoop neck and undulating hem. She starred alongside in 1983 horror musical Grizzly II: The Concert

Unique! Multi-talented Anna Kendrick, 32, arrived in a very unique white dress that looked as though it was composed of wide strips of fabric

Way back when: She said: 'George was so nice. I didn’t meet him until we were on set together. There was the first thing we shot together, we were doing a sort of walk-and-talk, and we were waiting to go, and he was like under his breath: “Do you get nervous? I get nervous" (Anna and George at the 2009 premiere of Up In The Air)

Two of a kind! Funnyman Jimmy Kimmel brought along his wife Molly McNearney as the both put on a dazzling display

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