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Body Weight Fluctuations Linked to More Deaths in People with Coronary Artery Disease

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NEW YORK, April 5, 2017 /360WiseNews/ — Repeated cycles of weight loss and gain may be linked to higher risk for stroke, heart attack, and death in people with pre-existing coronary artery disease, according to a study published online April, 5 in the New England Journal of Medicine.

Led by researchers at NYU Langone Medical Center, the study was the first to measure the effect of “weight cycling” on health outcomes in people with pre-existing heart disease. People with the largest weight changes were found to experience 136 percent more strokes, 117 percent more heart attacks, and 124 percent more deaths than those with the smallest shifts in weight.

Those in the high-fluctuation group had weight changes as large as 3.9 kilograms (or roughly 8.6 pounds), while weight varied by around 0.9 kilograms (just under 2 pounds) in the group with the smallest shifts in weight.

“Our findings suggest that we need to be concerned about weight fluctuation in this group that is already at high risk due to coronary disease,” says lead study author Sripal Bangalore, MD, director of the cardiovascular outcomes group in the Cardiovascular Clinical Research Center at NYU Langone.

“Even though this analysis was not designed to find out the causes of increased risk with body weight fluctuations, we need to examine how we can help Americans keep weight off, rather than having it go up and down,” says Bangalore, an associate professor of medicine in the Leon H. Charney Division of Cardiology. Keep Reading

North Dallas Research Associates and Cardiac Center of Texas Begin Enrollment in TOBA II BTK Clinical Trial for New Peripheral Revascularization Treatment Option

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Dr. Khan Deployed the First Below the Knee Tack System in the South East Region and Only Second in the Country

MCKINNEY, Texas, March 2, 2017 /360WiseNews/ — North Dallas Research Associates and its private practice, Cardiac Center of Texas, announced today their participation in the Tack Optimized Balloon Angioplasty II Below the Knee (TOBA II BTK) clinical trial. TOBA II BTK is a study that offers physicians a new option to treat patients suffering from advanced peripheral artery disease (PAD) or critical limb ischemia (CLI). Using the Tack Endovascular System®, the innovative technology is designed specifically to repair dissections following standard balloon angioplasty in the popliteal and tibial arteries with minimal stress to the vessels.

“We’re very excited to enroll the first patient in Texas to be treated in this groundbreaking clinical study,” said Dr. M. Akram Khan, Cardiologist at Cardiac Center of Texas. “TOBA II BTK provides the latest vascular technology for those in the Dallas area suffering from advanced PAD.”

PAD is a disease of the blood vessels in the legs and feet that occurs when arteries become narrow or clogged and don’t receive enough blood flow to meet the body’s needs. A recent analysis suggests more than 8 million Americans have peripheral artery disease, with 12-20% of individuals ages 65+ being affected. When left untreated, PAD can lead to critical limb ischemia (CLI), a more serious form of the disease. There are more than one million people in the United States living with CLI. CLI patients experience similar symptoms to PAD patients; however, CLI symptoms can significantly increase in severity from pain when resting, to open sores, to life-threatening conditions like gangrene, and can eventually require limb amputation in some patients. According to the U.S. Department of Health and Human Services, clogged arteries in the legs, just like clogged arteries in the heart, put individuals at risk for heart attack or stroke.

The Tack Endovascular System is equipped with self-sizing technology that allows one Tack implant to fit arteries ranging from 1.5mm to 4.5mm in diameter. This flexibility eliminates the need to precisely size the device to the arterial diameter, which is necessary with conventional stents. The device then allows physicians to “spot treat” the vessel only where dissections are present, rather than leave dissections untreated or covering them with large metal stents. This technique minimizes the amount of implanted metal and reduces vessel trauma and inflammation.

“Advanced PAD and CLI are large areas of fast-growing unmet need, both clinically and from a health economics perspective,” added Dr. Khan. “Patients with CLI suffer from debilitating symptoms and have few effective treatment options. It is important for the medical community to collaborate in this study to further the treatment options for patients with such advanced disease.”

Additional information regarding this trial can be found at clinicaltrials.gov by searching the term NCT02522884.

About the Tack Endovascular System and the TOBA II BTK Clinical Trial
For more information about the TOBA II BTK trial, please visit www.intactvascular.com

About North Dallas Research Associates and Cardiac Center of Texas
Established in 2003 by Dr. M. Akram Khan, NDRA has grown steadily for more than 10 years building expertise in clinical research operations. We are a team of professional and dedicated staff led by Dr. Khan, who manages and conducts a vast variety of clinical trials. Currently, the site has three principal investigators conducting clinical trials under various specialties. Keep Reading

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